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hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Therefore, the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biologicalIn this design, MBI-CN conjugates to mitochondrial DNA without causing additional damages.Give that the specific and rapid response of MBI-CN does not cause additional damages to mitochondrialDNA, it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA

Keywords： hydrolysis reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: Hepatocellular carcinoma (HCC), which makes up the majority of liver cancer, is induced by the infection of hepatitis B/C virus. Biomarkers are needed to facilitate the early detection of HCC, which is often diagnosed too late for effective therapy. The tRNA-derived small RNAs (tsRNAs) play vital roles in tumorigenesis and are stable in circulation. However, the diagnostic values and biological functions of circulating tsRNAs, especially for HCC, are still unknown. In this study, we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum. We identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCC patients vs. 24 healthy controls). In the validation stage, we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity (80.4%) and specificity (79.4%) even in the early stage (Stage I: sensitivity, 79.0%; specificity, 74.8%; 155 healthy controls vs. 153 HCC patients from two cohorts). Moreover, in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells, and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays. In summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: The signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 358-365 doi: 10.15302/J-FASE-2017158

Abstract: Substantial variation in gene organization and arrangement has been reported for sequenced mitochondrial

Keywords： gene rearrangement     mitochondrial genome     Psocoptera     Stenopsocidae     TDRL model    

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N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 472-485 doi: 10.1007/s11684-021-0832-y

Abstract: in rats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing mitochondrialmetabolism.In this work, the mitochondrial metabolism of hypoxia-conditioned NPCs (hcNPCs) was upregulated via themetabolism.metabolism.

Keywords： neuronal progenitor cells     resveratrol     cerebral ischemia     neuronal differentiation     mitochondrial metabolism    

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Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 256-266 doi: 10.1007/s11783-013-0585-1

Abstract: Vanadium is a vital strategic resource, and vanadium metabolism is an important part of the nationalThis study conducts accounting and scenario analysis on the life cycle of vanadium metabolism in ChinaA scenario analysis was conducted to analyze the future developmental trend of vanadium metabolism in

Keywords： metabolism     vanadium industry     substance flow analysis     scenario analysis    

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract: particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

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Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested byBoth enzymes play an important role in lipid metabolism and are associated with tumor-related signalingarticle introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: Direct DNA-sequencing analysis techniques were used to detect mitochondrial sequence variants between

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1035-x

Abstract: Anammox (ANaerobic AMMonia OXidation) is a newly discovered pathway in the nitrogen cycle. This discovery has increased our knowledge of the global nitrogen cycle and triggered intense interest for anammox-based applications. Anammox bacteria are almost ubiquitous in the suboxic zones of almost all types of natural ecosystems and contribute significant to the global total nitrogen loss. In this paper, their ecological distributions and contributions to the nitrogen loss in marine, wetland, terrestrial ecosystems, and even extreme environments were reviewed. The unique metabolic mechanism of anammox bacteria was well described, including the particular cellular structures and genome compositions, which indicate the special evolutionary status of anammox bacteria. Finally, the ecological interactions among anammox bacteria and other organisms were discussed based on substrate availability and spatial organizations. This review attempts to summarize the fundamental understanding of anammox, provide an up-to-date summary of the knowledge of the overall anammox status, and propose future prospects for anammox. Based on novel findings, the metagenome has become a powerful tool for the genomic analysis of communities containing anammox bacteria; the metabolic diversity and biogeochemistry in the global nitrogen budget require more comprehensive studies.

Keywords： Anammox     Metabolism     Metagenome     Ecological distribution     Microbial interactions    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer cells generate energy through increased glucose metabolism.Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generationHere, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions

Weihua ZENG,Bo WU,Ying CHAI

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 1,   Pages 114-128 doi: 10.1007/s11783-014-0669-6

Abstract: A revised concept for urban water metabolism (UWM) is presented in this study to address the inadequaciescan be analyzed to increase the water environmental carrying capacity (WECC) of the new urban water metabolism

Keywords： urban water metabolism system (UWMS)     system dynamic simulation     water environmental carrying capacity    

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Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 131-136 doi: 10.15302/J-FASE-2016096

Abstract: The accumulation of AsA, the expression patterns of the nine genes related to AsA metabolism as well

Keywords： Chinese jujube     ascorbic acid     metabolism     gene     enzyme    

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Title Author Date Type Operation

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Journal Article

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia

Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang

Journal Article

Vanadium metabolism investigation using substance flow and scenario analysis

Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions

Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions

Weihua ZENG,Bo WU,Ying CHAI

Journal Article

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Journal Article